Luminal Progenitor Cells— ( I know…say what?)

BRCA NEWSWORTHY

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. By the following:

Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat ML, Gyorki DE, Ward T, Partanen A, Feleppa F, Huschtscha LI, Thorne HJ; kConFab, Fox SB, Yan M, French JD, Brown MA, Smyth GK, Visvader JE, Lindeman GJ.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

Nat Med. 2009 Aug;15(8):907-13. Epub 2009 Aug 2. PMID: 19648928 [PubMed - in process]

Follow this link please: http://www.ncbi.nlm.nih.gov/pubmed/19648928

Researchers have found that breast tissue from BRCA1 positive women have large “luminal progenitor cells.” Originally it was thought that basal like breast cancers in BRCA1 positive women originated from the mammary stem cell, now it is being suggested that these cancers are from abnormal luminal progenitor cells.

When researchers find the reasons for cell changes causing breast cancer they will be able to target therapy cures to them.