BRCA & Breast Cancer research article from the ScienceDaily.com 11/2/08

BRCA NEWSWORTHY

New Tumor Inhibitor for Treatment of Hereditary Breast Cancer Shows Promising Results in Mouse Model.Journal reference:Sven Rottenberg, Janneke E. Jaspers, Ariena Kersbergen, Eline van der Burg, Anders O. H. Nygren, Serge A. L. Zander, Patrick W. B. Derksen, Michiel de Bruin, John Zevenhoven, Alan Lau, Robert Boulter, Aaron Cranston, Mark J. O’Connor, Niall M. B. Martin, Piet Borst, and Jos Jonkers. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. PNAS Online Early Edition, October 29, 2008

Netherlands Cancer Institute (2008, November 2). New Tumor Inhibitor For Treatment Of Hereditary Breast Cancer Shows Promising Results In Mouse Model. ScienceDaily. Retrieved November 6, 2008, from http://www.sciencedaily.com­ /releases/2008/10/081030075651.htm

Full article at: http://www.sciencedaily.com/releases/2008/10/081030075651.htm

Researchers of the Netherlands Cancer Institute have recently started human trials of an “inhibitor” AZD2281 to stop breast cancer in BRCA1 gene mutations. This inhibitor developed drug resistance long term in the mouse model but was reversed after using another inhibitor, so researchers feel the AZD2281 helps make it more effective. This mouse model is a good test for future new anti-cancer drugs.